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1

In vitro autoradiography and in vivo evaluation in cynomolgus monkey of [18F]FE-PE2I, a new dopamine transporter PET radioligand

Andrea Varrone, Carsten Steiger, Magnus Schou, Akihiro Takano, Sjoerd J. Finnema, Denis Guilloteau, Balázs Gulyás, Christer Halldin

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 316 KB

english, 2009

2

Synthesis and PET evaluation of (R)-[S-methyl-11C]thionisoxetine, a candidate radioligand for imaging brain norepinephrine transporters

Magnus Schou, Victor W. Pike, Andrea Varrone, Balázs Gulyás, Lars Farde, Christer Halldin

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Année:

2006

Langue:

english

Fichier:

PDF, 164 KB

english, 2006

3

Radiolabeling of a high potency cannabinoid subtype-1 receptor ligand, N-(4-fluoro-benzyl)-4-(3-(piperidin-1-yl)-indole-1-sulfonyl)benzamide (PipISB), with carbon-11 or fluorine-18

Sean R. Donohue, Christer Halldin, Magnus Schou, Jinsoo Hong, Lee Phebus, Eyassu Chernet, Stephen A. Hitchcock, Kevin M. Gardinier, Kevin M. Ruley, Joseph H. Krushinski, John Schaus, Victor W. Pike

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Année:

2008

Langue:

english

Fichier:

PDF, 216 KB

english, 2008

4

Synthesis of a delta opioid agonist in [2H6], [2H4], [11C], and [14C] labeled forms

Charles S. Elmore, Kelly Brush, Magnus Schou, William Palmer, Peter N. Dorff, Mark E. Powell, Valerie Hoesch, James E. Hall, Thomas Hudzik, Christer Halldin, Cathy L. Dantzman

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Année:

2011

Langue:

english

Fichier:

PDF, 1.77 MB

english, 2011

5

Synthesis of 3H-labeled N-(3-iodoprop-2E-enyl)-2β-carbomethoxy-3β-(4-methylphenyl)nortropane (PE2I) and its interaction with mice striatal membrane fragments

Vladimir Stepanov, Magnus Schou, Jaak Järv, Christer Halldin

Journal:

Applied Radiation and Isotopes

Année:

2007

Langue:

english

Fichier:

PDF, 238 KB

english, 2007

6

Synthesis of 11C-labelled (R)-OHDMI and CFMME and their evaluation as candidate radioligands for imaging central norepinephrine transporters with PET

Magnus Schou, Victor W. Pike, Judit Sóvágó, Balázs Gulyás, Peter T. Gallagher, David R. Dobson, Magnus W. Walter, Helene Rudyk, Lars Farde, Christer Halldin

Journal:

Bioorganic & Medicinal Chemistry

Année:

2007

Langue:

english

Fichier:

PDF, 302 KB

english, 2007

7

Synthesis, radiolabeling and preliminary in vivo evaluation of [18F]FE-PE2I, a new probe for the dopamine transporter

Magnus Schou, Carsten Steiger, Andrea Varrone, Denis Guilloteau, Christer Halldin

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2009

Langue:

english

Fichier:

PDF, 239 KB

english, 2009

8

The influence of diet consistence, drinking water and bedding on periodontal disease in Sprague-Dawley rats

Magnús Jón Björnsson, Sten Velschow, Kaj Stoltze, Anne Havemose-Poulsen, Søren Schou, Palle Holmstrup

Journal:

Journal of Periodontal Research

Année:

2003

Langue:

english

Fichier:

PDF, 274 KB

english, 2003

9

PET evaluation of novel radiofluorinated reboxetine analogs as norepinephrine transporter probes in the monkey brain

Magnus Schou, Christer Halldin, Judit Sóvágó, Victor W. Pike, Håkan Hall, Balázs Gulyás, P. David Mozley, David Dobson, E. Shchukin, Robert B. Innis, Lars Farde

Journal:

Année:

2004

Langue:

english

Fichier:

PDF, 550 KB

english, 2004

10

Specific in vitro binding of (S,S)-[3H]MeNER to norepinephrine transporters

Subroto Ghose, Masahiro Fujita, Paul Morrison, George Uhl, Dennis L. Murphy, P. David Mozley, Magnus Schou, Christer Halldin, Robert Innis

Journal:

Année:

2005

Langue:

english

Fichier:

PDF, 209 KB

english, 2005

11

Atomoxetine occupies the norepinephrine transporter in a dose-dependent fashion: a PET study in nonhuman primate brain using (S,S)-[18F]FMeNER-D2

Nicholas Seneca, Balázs Gulyás, Andrea Varrone, Magnus Schou, Anu Airaksinen, Johannes Tauscher, Francois Vandenhende, William Kielbasa, Lars Farde, Robert B. Innis, Christer Halldin

Journal:

Psychopharmacology

Année:

2006

Langue:

english

Fichier:

PDF, 266 KB

english, 2006

12

Imaging the norepinephrine transporter with positron emission tomography: initial human studies with (S,S)-[18F]FMeNER-D2

Akihiro Takano, Balázs Gulyás, Andrea Varrone, Per Karlsson, Magnus Schou, Anu J. Airaksinen, Francois Vandenhende, Johannes Tauscher, Christer Halldin

Journal:

European Journal of Nuclear Medicine and Molecular Imaging

Année:

2008

Langue:

english

Fichier:

PDF, 229 KB

english, 2008

13

Biodistribution and radiation dosimetry of the norepinephrine transporter radioligand (S,S)-[18F]FMeNER-D2: a human whole-body PET study

Akihiro Takano, Christer Halldin, Andrea Varrone, Per Karlsson, Nils Sjöholm, James B. Stubbs, Magnus Schou, Anu J. Airaksinen, Johannes Tauscher, Balázs Gulyás

Journal:

European Journal of Nuclear Medicine and Molecular Imaging

Année:

2008

Langue:

english

Fichier:

PDF, 199 KB

english, 2008

14

Synthesis and Positron Emission Tomography Evaluation of Three Norepinephrine Transporter Radioligands: [C-11]Desipramine, [C-11]Talopram and [C-11]Talsupram

Magnus Schou, Judit Sóvágó, Victor W. Pike, Balázs Gulyás, Klaus P. Bøgesø, Lars Farde, Christer Halldin

Journal:

Molecular Imaging and Biology

Année:

2006

Langue:

english

Fichier:

PDF, 701 KB

english, 2006

15

Investigation of the Metabolites of (S,S)-[11C]MeNER in Humans, Monkeys and Rats

Magnus Schou, Sami S. Zoghbi, H. Umesha Shetty, Evgeny Shchukin, Jeih-San Liow, Jinsoo Hong, Bengt A. Andrée, Balázs Gulyás, Lars Farde, Robert B. Innis, Victor W. Pike, Christer Halldin

Journal:

Molecular Imaging and Biology

Année:

2009

Langue:

english

Fichier:

PDF, 183 KB

english, 2009

16

Rapid and sensitive measurement of PET radioligands in plasma by fast liquid chromatography/radiometric detection

Ryuji Nakao, Magnus Schou, Christer Halldin

Journal:

Journal of Chromatography B

Année:

2012

Langue:

english

Fichier:

PDF, 715 KB

english, 2012

17

Synthesis and evaluation of pyridylbenzofuran, pyridylbenzothiazole and pyridylbenzoxazole derivatives as 18F-PET imaging agents for β-amyloid plaques

Britt-Marie Swahn, Johan Sandell, David Pyring, Margareta Bergh, Fredrik Jeppsson, Anders Juréus, Jan Neelissen, Peter Johnström, Magnus Schou, Samuel Svensson

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2012

Langue:

english

Fichier:

PDF, 974 KB

english, 2012

18

Lack of effect of reserpine-induced dopamine depletion on the binding of the dopamine-D3 selective radioligand, [11C]RGH-1756

Judit Sóvágó, Lars Farde, Christer Halldin, Evgenij Schukin, Magnus Schou, István Laszlovszky, Béla Kiss, Balázs Gulyás

Journal:

Brain Research Bulletin

Année:

2005

Langue:

english

Fichier:

PDF, 240 KB

english, 2005

19

Specific in vivo binding to the norepinephrine transporter demonstrated with the PET radioligand, (S,S)-[11C]MeNER

Magnus Schou, Christer Halldin, Judit Sóvágó, Victor W Pike, Balázs Gulyás, P.David Mozley, David P Johnson, Håkan Hall, Robert B Innis, Lars Farde

Journal:

Nuclear Medicine and Biology

Année:

2003

Langue:

english

Fichier:

PDF, 338 KB

english, 2003

20

A Total Synthesis of Hydroxylysine in Protected Form and Investigations of the Reductive Opening of p -Methoxybenzylidene Acetals

Gustafsson, Tomas, Schou, Magnus, Almqvist, Fredrik, Kihlberg, Jan

Journal:

Journal of Organic Chemistry

Année:

2004

Langue:

english

Fichier:

PDF, 160 KB

english, 2004

21

Post-mortem human brain autoradiography of the norepinephrine transporter using (S,S)-[18F]FMeNER-D2

Magnus Schou, Christer Halldin, Victor W. Pike, P. David Mozley, David Dobson, Robert B. Innis, Lars Farde, Håkan Hall

Journal:

European Neuropsychopharmacology

Année:

2005

Langue:

english

Fichier:

PDF, 1.46 MB

english, 2005

22

Synthesis of 11C-labeled (S,S)-CFMME and (R)-OHDMI and their evaluation as candidate radioligands for imaging norepinephrine transporters with PET

Magnus Schou, V.W. Pike, J. Sóvágó, B. Gulyás, P. Gallagher, D. Dobson, M.W. Walter, H. Rudyk, L. Farde, C. Halldin

Journal:

Année:

2006

Langue:

english

Fichier:

PDF, 52 KB

english, 2006

23

Radiolabeling of two 11 C-labeled formylating agents and their application in the preparation of [ 11 C]benzimidazole

Schou, Magnus, Halldin, Christer

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Année:

2012

Langue:

english

Fichier:

PDF, 177 KB

english, 2012

24

Radiofluorination and reductive amination using a microfluidic device

Dahl, Kenneth, Schou, Magnus, Halldin, Christer

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Année:

2012

Langue:

english

Fichier:

PDF, 208 KB

english, 2012

25

[18F]AZD4694—A new PET radioligand for sensitive detection of β-amyloid deposits

Anders Juréus, Britt-Marie Swahn, Johan Sandell, Fredrik Jeppsson, Jan A.M. Neelissen, Christer Halldin, Peter Johnström, Magnus Schou, Zsolts Cselényi, Lars Farde, Samuel P.S. Svensson

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 48 KB

english, 2010

26

Quantification and wavelet-aided parametric imaging of cerebral amyloid using the HRRT PET-system and [18F]AZD4694

Zsolt Cselényi, Maria Eriksdotter Jönhagen, Anton Forsberg, Christer Halldin, Per Julin, Magnus Schou, Peter Johnström, Katarina Varnäs, Samuel Svensson, Lars Farde

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 120 KB

english, 2010

27

Palladium-Mediated [ 11 C]Carbonylation at Atmospheric Pressure: A General Method Using Xantphos as Supporting Ligand

Dahl, Kenneth, Schou, Magnus, Amini, Nahid, Halldin, Christer

Journal:

European Journal of Organic Chemistry

Année:

2013

Langue:

english

Fichier:

PDF, 327 KB

english, 2013

28

Identification of PET radiometabolites by cytochrome P450, UHPLC/Q-ToF-MS and fast radio-LC: applied to the PET radioligands [11C]flumazenil, [18F]FE-PE2I, and [11C]PBR28

Amini, Nahid, Nakao, Ryuji, Schou, Magnus, Halldin, Christer

Journal:

Analytical and Bioanalytical Chemistry

Année:

2013

Langue:

english

Fichier:

PDF, 623 KB

english, 2013

29

Radiolabeling of the cannabinoid receptor agonist AZD1940 with carbon-11 and PET microdosing in non-human primate

Schou, Magnus, Varnäs, Katarina, Jucaite, Aurelija, Gulyás, Balázs, Halldin, Christer, Farde, Lars

Journal:

Nuclear Medicine and Biology

Année:

2013

Langue:

english

Fichier:

PDF, 342 KB

english, 2013

30

Rapid metabolite analysis of positron emission tomography radioligands by direct plasma injection combining micellar cleanup with high submicellar liquid chromatography with radiometric detection

Nakao, Ryuji, Schou, Magnus, Halldin, Christer

Journal:

Journal of Chromatography A

Année:

2012

Langue:

english

Fichier:

PDF, 495 KB

english, 2012

31

Determination of plasma protein binding of positron emission tomography radioligands by high-performance frontal analysis

Amini, Nahid, Nakao, Ryuji, Schou, Magnus, Halldin, Christer

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Année:

2014

Langue:

english

Fichier:

PDF, 699 KB

english, 2014

32

Synthesis, Radiolabeling, andIn VivoPharmacokinetic Evaluation of the Amyloid Beta Radioligand [11C]AZD4694 in Nonhuman Primates

Schou, Magnus, Varnäs, Katarina, Sandell, Johan, Johnström, Peter, Cselenyi, Zsolt, Svensson, Samuel, Nakao, Ryuji, Amini, Nahid, Bergman, Linda, Sumic, Anna, Gulyas, Balazs, Lindström-Böö, Eva, Halld

Journal:

Molecular Imaging and Biology

Année:

2014

Langue:

english

Fichier:

PDF, 2.82 MB

english, 2014

33

Improved Yields for the Palladium-Mediated 11 C-Carbonylation Reaction Using Microwave Technology

Dahl, Kenneth, Schou, Magnus, Rahman, Obaidur, Halldin, Christer

Journal:

European Journal of Organic Chemistry

Année:

2014

Langue:

english

Fichier:

PDF, 452 KB

english, 2014

34

Direct Plasma Metabolite Analysis of Positron Emission Tomography Radioligands by Micellar Liquid Chromatography with Radiometric Detection

Nakao, Ryuji, Schou, Magnus, Halldin, Christer

Journal:

Analytical Chemistry

Année:

2012

Langue:

english

Fichier:

PDF, 872 KB

english, 2012

35

Identification of positron emission tomography (PET) tracer candidates by prediction of the target-bound fraction in the brain

Fridén, Markus, Wennerberg, Marie, Antonsson, Madeleine, Sandberg-Ställ, Maria, Farde, Lars, Schou, Magnus

Journal:

EJNMMI Research

Année:

2014

Langue:

english

Fichier:

PDF, 861 KB

english, 2014

36

Development of Radioligands for Imaging of Brain Norepinephrine Transporters In Vivo with Positron Emission Tomography

Schou, Magnus, Pike, Victor, Halldin, Christer

Journal:

Current Topics in Medicinal Chemistry

Année:

2007

Langue:

english

Fichier:

PDF, 278 KB

english, 2007

37

Large Variation in Brain Exposure of Reference CNS Drugs: a PET Study in Nonhuman Primates

Schou, Magnus, Varnäs, Katarina, Lundquist, Stefan, Nakao, Ryuji, Amini, Nahid, Takano, Akihiro, Finnema, Sjoerd J., Halldin, Christer, Farde, Lars

Journal:

The International Journal of Neuropsychopharmacology

Année:

2015

Langue:

english

Fichier:

PDF, 1.03 MB

english, 2015

38

Discovery and Preclinical Validation of [ 11 C]AZ13153556, a Novel Probe for the Histamine Type 3 Receptor

Schou, Magnus, Varnäs, Katarina, Jureus, Anders, Ahlgren, Charlotte, Malmquist, Jonas, Häggkvist, Jenny, Tari, Lenke, Wesolowski, Steven S., Throner, Scott R., Brown, Dean G., Nilsson, Maria, Johnströ

Journal:

ACS Chemical Neuroscience

Année:

2016

Langue:

english

Fichier:

PDF, 3.37 MB

english, 2016

39

Direct and Efficient (Carbonyl)cobalt-Mediated Aryl Acetylation Using [11C]Methyl Iodide

Dahl, Kenneth, Schou, Magnus, Halldin, Christer

Journal:

European Journal of Organic Chemistry

Année:

2016

Langue:

english

Fichier:

PDF, 394 KB

english, 2016

40

An evaluation of a high-pressure 11 CO carbonylation apparatus

Dahl, Kenneth, Itsenko, Oleksiy, Rahman, Obaidur, Ulin, Johan, Sjöberg, Carl-Olof, Sandblom, Peter, Larsson, Lars-Anders, Schou, Magnus, Halldin, Christer

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Année:

2015

Langue:

english

Fichier:

PDF, 278 KB

english, 2015

41

Whole-body biodistribution, radiation dosimetry estimates for the PET norepinephrine transporter probe (S,S)-[18F]FMeNER-D2 in non-human primates

Seneca, Nicholas, Andree, Bengt, Sjoholm, Nils, Schou, Magnus, Pauli, Stefan, Mozley, P. David, Stubbs, James B., Liow, Jeih-San, Sovago, Judit, Guly??s, Balazs, Innis, Robert, Halldin, Christer

Journal:

Nuclear Medicine Communications

Année:

2005

Langue:

english

Fichier:

PDF, 113 KB

english, 2005

42

Efficient DBU accelerated synthesis of 18F-labelled trifluoroacetamides.

Bermejo Gómez, Antonio, Cortes, Miguel, Luebcke, Marvin, Johansson, Magnus, HALLDIN, Christer, Szabo, Kalman J., Schou, Magnus

Journal:

Chemical Communications

Année:

2016

Langue:

english

Fichier:

PDF, 836 KB

english, 2016

43

11 C-carbonylation reactions using gas–liquid segmented microfluidics

Dahl, Kenneth, Schou, Magnus, Ulin, Johan, Sjöberg, Carl-Olof, Farde, Lars, Halldin, Christer

Journal:

Année:

2015

Langue:

english

Fichier:

PDF, 351 KB

english, 2015

44

Synthesis of trifluoromethyl moieties by late-stage copper (I) mediated nucleophilic fluorination

Bermejo Góme, Antonio, González, Miguel A. Cortés, Lübcke, Marvin, Johansson, Magnus J., Schou, Magnus, Szabó, Kálmán J.

Journal:

Journal of Fluorine Chemistry

Année:

2017

Langue:

english

Fichier:

PDF, 783 KB

english, 2017

45

PET microdosing of CNS drugs

Schou, Magnus, Varnäs, Katarina

Journal:

Clinical and Translational Imaging

Année:

2017

Langue:

english

Fichier:

PDF, 577 KB

english, 2017

46

New methodologies for the preparation of carbon-11 labeled radiopharmaceuticals

Dahl, Kenneth, Halldin, Christer, Schou, Magnus

Journal:

Clinical and Translational Imaging

Année:

2017

Langue:

english

Fichier:

PDF, 2.41 MB

english, 2017

47

[ 11 C]AZ10419096 - a full antagonist PET radioligand for imaging brain 5-HT 1B receptors

Lindberg, Anton, Nag, Sangram, Schou, Magnus, Takano, Akihiro, Matsumoto, Junya, Amini, Nahid, Elmore, Charles S., Farde, Lars, Pike, Victor W., Halldin, Christer

Journal:

Nuclear Medicine and Biology

Année:

2017

Langue:

english

Fichier:

PDF, 1.12 MB

english, 2017

48

Discovery of a Novel Muscarinic Receptor PET Radioligand with Rapid Kinetics in the Monkey Brain

Malmquist, Jonas, Varnas, Katarina, Svedberg, Marie, Vallée, Frédéric, Albert, Jeffery S., Finnema, Sjoerd J, Schou, Magnus

Journal:

ACS Chemical Neuroscience

Année:

2017

Langue:

english

Fichier:

PDF, 1.24 MB

english, 2017

49

Reduction of [ 11 C]CO 2 to [ 11 C]CO using solid supported zinc

Dahl, Kenneth, Ulin, Johan, Schou, Magnus, Halldin, Christer

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Année:

2017

Langue:

english

Fichier:

PDF, 196 KB

english, 2017

50

Development of [carbonyl-11C]AZ13198083, a novel histamine type-3 receptor radioligand with favorable kinetics

Dahl, Kenneth, Nakao, Ryuji, Amini, Nahid, Moein, Mohammad Mahdi, Finnema, Sjoerd J, Malmquist, Jonas, Varnas, Katarina, Schou, Magnus

Journal:

ACS Chemical Neuroscience

Année:

2018

Langue:

english

Fichier:

PDF, 778 KB

english, 2018